Irbesartan/Hydrochlorothiazide 150/12.5mg

What Irbesartan/Hydrochlorothiazide is used for:

• It is a combination of Irbesartan, an angiotensin II receptor antagonist, and Hydrochlorothiazide, a thiazide diuretic, indicated for hypertension:
• In patients not adequately controlled with monotherapy.
• As initial therapy in patients likely to need multiple drugs to achieve their blood pressure goal.

Do not take Irbesartan/Hydrochlorothiazide if:

• Hypersensitivity to Irbesartan or hydrochlorothiazide 
• Hypersensitivity to sulfonamide-derived drugs (like sulfamethoxazole/trimethoprim, sulfasalazine)
• Anuria present (not enough urine production)
• Renal impairment
• Liver impairment

Warnings & Precautions:

• Talk to your doctor or pharmacist before taking Irbesartan/Hydrochlorothiazide
• To monitor kidney functions 
• To monitor potassium levels 
• If you have vision problems like myopia or glaucoma
• If you have lupus 
• If you are at risk to be volume depleted (dehydrated)

Possible Side Effects: 

• Fatigue 
• Dizziness
• Muscle pain

Other medicines and Irbesartan/hydrochlorothiazide:

• Tell your doctor or pharmacist about all medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements.
• Increased risk of kidney damage and reduction of its effects when taken with Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and COX-2 inhibitors (like ibuprofen, ketoprfen, celecoxib)
• Increased risk of lithium toxicity when taken together
• Not recommended use with potassium supplements to avoid increase of potassium levels in blood.

With only Hydrochlorothiazide:

• Avoid cholestyramine and colestipol to have maximum absorption
• Adjust dose of antidiabetics 
• Monitor while using alcohol, barbiturates and narcotics because of the potential hypotension

How to take Irbesartan/hydrochlorothiazide:

• Adults above 18 years of age and CrCl >30ml/min: 
• The usual dose is: 1 tablet daily 
• Irbesartan//hydrochlorothiazide tablet can be taken with or without food 
• It may be administered with other antihypertensive agents 
• It can be taken any time of the day 
• Do not break the tablet in half 
• Correct if known volume depletion prior to starting the medicine

How to store Irbesartan/hydrochlorothiazide:

• Keep this medicine out of the sight and reach of children.
• Store at Room Temperature [77°F (25°C)]. 
• Do not store above 30°